I generally read a lot of feeds. I probably currently subscribe to about 120 (thankfully not all of which are updated daily). For the longest time, I was using bloglines as my reader of choice. When Google updated it's Reader product, I quickly migrated my OPML feed over there. I liked Google's similar interface to Gmail, and the community sharing feature was kind of cool too. Still, I yearned for more.
I had heard countless people talk about NetNewsWire to me but until the other day I really had not tried it. I thought I really wanted a web-based reader (I know NetNewsWire works seamlessly with Newsgator.com). As soon as I imported my subscriptions, I was hooked. The interface is very similar to Mail in OS X, even with Smart Lists. There's also a built-in browser, integration with apps like iCal, iPhoto, Growl, Address Book, and so forth. Add to that .Mac syncing and an iPhone app that blows Google Reader out of the water.
Yes, I'm totally a fan. And best of all, NetNewsWire is now free.